Irritable bowel syndrome (IBS) is the most frequent diagnosis in gastroenterology and primary care practices; however, there are few treatment options for patients with IBS with diarrhea.
The Case–A 24-year-old woman with history of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and diffuse B-cell lymphoma, actively receiving chemotherapy, was admitted with diarrhea and abdominal pain.
According to a 2011 report from the National Center for Health Statistics, approximately 11% of Americans 12 years and older took an antidepressant between 2005 and 2008, with more than one-third of patients with current severe depressive symptoms taking antidepressants.
It is a chronic condition that can be characterized by abdominal discomfort with altered bowel pattern for >3 months. IBS is diagnosed clinically because there is no known biomarker associated with the disorder. This makes estimating the prevalence of the disorder a difficult task, as clinicians use a variety of tools to make their diagnoses. However, it is estimated that approximately 10% to 15% of the adult population is affected by the disease. It is more commonly found in women and prevalence of the disorder also decreases with age, as most patients range in age from 15 to 65 years.
The over-the-counter (OTC) status of omeprazole and lansoprazole makes them highly accessible to many patients. Although generally regarded as safe, in the past several years PPIs have been associated with a number of adverse events, prompting the US Food and Drug Administration (FDA) to issue several labeling updates, including vitamin B (cyanocobalamin) deficiency, acute interstitial nephritis (AIN),4-8 Clostridium difficile–associated diarrhea (CDAD), and hypomagnesemia.
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